Chronic Leukemias

Chronic Leukemias

Chronic Leukemias are a type of blood cancer that develops more slowly compared to acute leukemias. In chronic leukemia, abnormal white blood cells grow and accumulate in the blood and bone marrow over time, disrupting the production of healthy blood cells. Because it progresses gradually, chronic leukemia may not cause noticeable symptoms for many years, but timely diagnosis and treatment are essential to manage the condition effectively.

Types of Chronic Leukemias

Chronic leukemias are broadly categorized into two main types based on the type of white blood cells affected

  • Chronic Lymphocytic Leukemia (CLL): CLL primarily affects lymphoid cells, a type of white blood cell involved in immune defense. It is the most common type of leukemia in adults and usually progresses slowly.

  • Chronic Myeloid Leukemia (CML): CML affects the myeloid cells, which develop into red blood cells, white blood cells, and platelets. CML progresses in phases and is characterized by the presence of an abnormal chromosome called the Philadelphia chromosome.

Symptoms of Chronic Leukemias

Chronic leukemia often develops without noticeable symptoms in its early stages. As the disease progresses, common symptoms may include:

  • Fatigue and weakness
  • Frequent infections
  • Unexplained weight loss
  • Swollen lymph nodes or an enlarged spleen
  • Easy bruising or bleeding
  • Night sweats and fever
  • Bone pain or discomfort

Because chronic leukemia progresses slowly, some patients may live with the disease for many years without significant symptoms, making regular health checkups crucial for early detection.

Diagnosis of Chronic Leukemias

To diagnose chronic leukemias, a series of tests may be conducted, including:

  • Blood tests to measure abnormal levels of white blood cells, red blood cells, and platelets.
  • Bone marrow biopsy to examine the bone marrow and identify cancerous cells.
  • Cytogenetic testing to look for genetic changes, such as the Philadelphia chromosome in CML.